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. 2010 Jul 5;207(7):1485–1500. doi: 10.1084/jem.20092695

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© 2010 Swanson et al.

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Figure 1. — Poly(I:C) enhances the antibody response to a model TI-2 antigen. (A) C57BL/6 mice were immunized with 5 µg NP-Ficoll alone or 5 µg NP-Ficoll + 100 µg poly(I:C) and serum NP-specific IgM, IgG3, and IgG2c antibodies were measured in preimmune (day 0 [d0]), day 4, and day 7 after immunization sera. Symbols represent individual mice, and horizontal bars indicate geometric mean. Data were combined from two independent experiments with five mice per group per experiment. *, P ≤ 0.005. (B) Total serum NP-specific IgG2c, IgG3, IgG2b, IgG1, and IgM were measured 7 d after immunization with NP-Ficoll ± poly(I:C). Data represent geometric means calculated from data combined from two independent experiments, with five mice per group per experiment. Geometric means from NP-specific IgM, IgG3, and IgG2c responses were the same as those represented in A.