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. 2010 Jul 5;207(7):1453–1464. doi: 10.1084/jem.20091474

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© 2010 Sander et al.

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Figure 5. — Recombinant SAA and KC are protective during sepsis. (A–D) Survival of gp130f/f mice compared with gp130Δhepa mice treated with SAA (A), KC (B), IL-1Ra (anakinra; C) or SAA and KC (D) in combination or equal volumes of NaCl 1 and 24 h after CLP (n = 9 per group; pooled data of three independent experiments). (E) Serum concentrations of IL-6 (left) and IFN-γ (right) at the indicated time points measured by ELISA. (F) Survival of gp130f/f mice treated with neutralizing anti-SAA antibodies or inactive control isotype IgG. (G) IFN-γ serum concentrations at the indicated time points after CLP in gp130f/f mice treated with anti-SAA or control antibodies (n = 6 per group; pooled data of two independent experiments). *, P < 0.05. Data are presented as means ± SEM.