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. 2010 Jul 5;207(7):1381–1391. doi: 10.1084/jem.20100004

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© 2010 Harada et al.

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Figure 2. — Cbl-b deficiency attenuates Foxp3⁺ iT reg cell differentiation in vivo. Naive OTII T cells (Vβ 5.1/5.2⁺) from WT and Cbl-b KO mice (CD45.2) were adoptively transferred to B6 SJL (CD45.1) mice, and the recipients were immunized with 10 µg of OVA_323-339 peptide (OVAp). 5 d after immunization, Foxp3 expression in CD45.2⁺TCR Vβ 5.1/5.2⁺ T cells were measured. ABI, axillary, branchial, and inguinal lymph nodes. (A) Representative FACS plots showing the percentage of Foxp3-expressing 5.1/5.2⁺ donor OTII T cells. Data are representative of three independent experiments. (B) Statistical representation of Foxp3 induction in donor OTII T cells. Each dot represents an individual mouse. Small horizontal lines indicate the mean, and error bars indicate standard deviations. **, P < 0.01; ***, P < 0.001. Data are from three independent experiments.