Table 1.
HDL-associated proteins identified using modem proteomic strategies
| Study |
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|---|---|---|---|---|---|---|
| Protein | Accession | 1 | 2 | 3 | 4 | 5 |
| Apo A-I | P02647 |
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| Apo A-II | P02652 |
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| Apo C-II | P02655 |
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| Apo C-III | P02656 |
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| Apo A-IV | P06727 |
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| Apo E | P02649 |
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| Apo L-I | O14791 |
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|
| SAA4 | P35542 |
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|
| SAA1&2 | P02735 |
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|
| Apo M | O95445 |
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| Apo D | P05090 |
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| Apo J | P10909 |
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| Pon 1 | P27169 |
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| HRP | P00739 |
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| Albumin | P02768 |
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| Apo C-I | P02654 |
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| α-1-antitrypsin | P01009 |
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| Serotransferrin | P02787 |
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| Transthyretin | P02766 |
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| Apo F | Q13790 |
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| α-1B-glycoprotein | P04217 |
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| CETP | P11597 |
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| Complement C3 | P01024 |
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| α1-acid glycoprotein 2 | P19652 |
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| α2-HS-glycoprotein | P02765 |
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| Vit-D Binding Protein | P02774 |
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| Apo C-IV | P55056 |
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| PLTP | P55058 |
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| Pon3 | Q15166 |
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| Fibrinogen | P02671 |
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| Apo B-100 | P04114 |
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| Apo H | P02749 |
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| Complement C4A | P0C0L4 |
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| Complement C9 | P02748 |
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| Vitronectin | P04004 |
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| α-2 antiplasmin | P08697 |
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| α-1-microglobulin | P02760 |
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| Inter α Trp. Inhib. | Q14624 |
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| Angiotensin | P01019 |
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| Kininogen-1 | P01042 |
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| Hemopexin | P02790 |
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| SERPINF1 | P36955 |
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| LCAT | P04180 |
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| Complement C4B | P0C0L5 |
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| Ret. Bind. Prot. 4 | P02753 |
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| Prenylcystein oxidase | Q9UHG3 |
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| LPL | P06858 |
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| C-RP | P02741 |
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| Ceruloplasmin | P00450 |
|
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| Serum Amyloid P | P02743 |
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| Complement Factor H | P08603 |
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| Kallikrein B1 | P03952 |
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| Factor VIII-assoc.prot | P00451 |
|
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| C1-INH | P05155 |
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| MSF-1 | P09603 |
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| Lymphocyte antigen | P06340 |
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| MGEA 5 | O60502 |
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| HLA-A protein | P04439 |
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| NOTCH 1 | P46531 |
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| Siglec 5 | O15389 |
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| CLECSF 1 | Q9P126 |
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| Zinc Finger Protein IA-1 | Q01101 |
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| LTBP-1 | P22064 |
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| LTBP-2 | Q14767 |
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| Gas6 | Q61592 |
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| Ryanodine receptor 2 | Q92736 |
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| POU 5 domain product | Q8N7G0 |
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| TFPI | P10646 |
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| Unnamed protein product | gi10435007 |
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| Unknown protein | gi12653035 |
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| Unknown protein | gi12802992 |
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| KIAA1095 | A8HTM6 |
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| KIAA1730 protein | Q9C0D3 |
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| KIAA0675 gene product | Q86Y13 |
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| ZNF 356 | Q9ULV3 |
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| dj675G8.1 | gi 11137825 |
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| dj733D15.1 | Q31N78 |
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| TAT-interactive protein | gi 1427566 |
|
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| dj758N20.1 | gi 11493357 |
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| PTP | gi 13645209 |
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| IgG | P99007 |
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| dj1057B20.2 | Q9NQG5 |
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| Desmocollin | Q08554 |
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| Alpha-amylase salivary | P04745 |
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| Alpha-2-macroglobulin | P01023 |
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| IDH | P50213 |
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| ACTA | P03996 |
|
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| Galectin-7 (LEG7) | P47929 |
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| Platelet basic protein | P02775 |
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| Prothrombin | P00734 |
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| PAF-AH | P43034 |
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| Apo(a) | P08519 |
|
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| Totals: | 93 | 46 | 57 | 13 | 24 | 28 |
Dark gray: protein found in all 5 studies; Medium gray: in 4 of 5 studies; Light gray: in 3 of 5 studies Author (Reference), HDL fraction used; HDL isolation technique; MS technique
1: Vaisar (29), Total HDL or HDL3; UC; ESI-MS/MS 2: Rezaee (28), Total HDL; UC-IDE or 2DE or ICAT; MALDI or nLC-MS/MS 3: Karlsson (25), HDL2 and HDL3; UC-2DE; MALDI 4: Heller (27), HDL2 and HDL3; UC-2DE; MALDI 5: Davidson (31), HDL2b,a & HDL3a,b,c; UC; ESI-MS/MS
Abbreviations: ESI, electrospray ionization; MALDI, matrix assisted laser desorption ionization; MS, mass spectrometry; UC, ultracentrifugation; x-DE, x dimensional electrophoresis