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DNA methylation status can affect variation in gene expression and drug response. A) For a particular drug response-related gene, there could be people with different epigenetic signatures within a population. Orange: sensitive people; Blue: nonrespondent people; white: all others. B) Sensitive people have an epigenetic signature that causes over-expression of the gene. C) In contrast, nonrespondent people have an epigenetic signature that inhibits gene expression.
