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. 2010 May 11;19(15):2974–2986. doi: 10.1093/hmg/ddq202

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© The Author 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Co-expression of SOD1-G93A and Bcl-2 induces mitochondrial structural damage. (A) Electron microscopy analysis of mitochondrial structure in HEK293T transfected with SOD1-WT (panels C and D), SOD1-G93A (panels E and F) without (upper panels A, C and E) or with (lower panels B, D and F) Bcl-2. Cells transfected with SOD1-G93A alone show structurally normal mitochondria (panel E), whereas co-expression of Bcl-2 and SOD1-G93A causes morphological changes as shown by extensive internal vacuolization and cristae disorganization (panel F). Images are representative of four experiments. (B) Transfection efficiency and expression levels of SOD1-eGFP and Bcl-2 among different experimental groups were assessed by WB with an anti-eGFP and Bcl-2 antibody, respectively.