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Distribution of anterior defects among genotypic classes (E9.5)
| Genotype | Chrd−/− | Nog+/− | Nog−/− | Nodal+/− | Smad3−/− |
| Sample no. | 36 | 68 | 39 | 18 | 44 |
| Anterior defects | 0 | 0 | 0 | 0 | 0 |
| Genotype | Chrd−/−;Nodal+/− | Nog−/−;Nodal+/− | Chrd−/−;Smad3+/− | Chrd−/−;Smad3−/− | |
| Sample no. | 83 | 22 | 37 | 25 | |
| Anterior defects | 19 (23%) | 0 | 0 | 0 | |
| Genotype | Nog+/−;Smad3+/− | Nog+/−;Smad3−/− | Nog−/−;Smad3+/− | Nog−/−;Smad3−/− | |
| Sample no. | 61 | 16 | 58 | 30 | |
| Anterior defects | 3 (5%) | 2 (13%) | 17 (29%) | 18 (60%) |
