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. 2010 May 28;4:19. doi: 10.3389/fncel.2010.00019

Figure 3.

Figure 3

PAFAH α1 and α2 catalytic subunits repress TCF/LEF-dependent transcription induced by CA β-catenin (A) or disheveled (Dvl) (B). HEK293 cells were transfected with either TOPFLASH, a reporter vector for the activation of the Wnt signaling, or FOPFLASH, a negative control reporter. In addition, different combinations of α1 and α2 on top of either TLE1 (A), or CRMP1 (B). Results are normalized as fold of induction relative to basal luciferase activity. Histograms represent the mean of three experiments ± S.E.M. Stars indicate the p values: **P < 0.01, ***P < 0.001.