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. 2010 May 28;4:19. doi: 10.3389/fncel.2010.00019

Figure 8.

Figure 8

Double KO mice exhibit advanced tangential migration. (A–D) GAD67-GFP-labeled interneurons are found in more advanced positions in double KO brain sections (A,B) in comparison with control sections (C,D). Scale bars in (A) and (C) is 100 μm, and in (B) and (D) is 40 μm. (E,F) Calbindin immunostaining, which identifies a subgroup of interneurons, demonstrates advanced positioning of these interneurons in the double KO (E,F) versus control (G,H). Scale bars in (E) and (G) is 100 μm, and in (F) and (H) is 40 μm. (I,J) Sdf-1 expression by in situ hybridization is expanded in the cortex of double KO (I) versus the control cortex (J). (K,L) In situ hybridization of Netrin-1 reveals an expanded expression in the striatum of double KO (K) versus the control striatum (L). Scale bars in (I–L) are 0.5 mm.