Skip to main content
. Author manuscript; available in PMC: 2010 Aug 6.
Published in final edited form as: DNA Repair (Amst). 2009 Jun 18;8(8):886–900. doi: 10.1016/j.dnarep.2009.05.004

FIG. 3.

FIG. 3

Increased frequency of inactivation of the HSV-tk gene as a result of I-SceI-induced DSBs near telomeres. The EJ-30 clones ΔB1 and ΔE2 containing interstitial I-SceI sites, and clones A4 and B3 containing telomeric I-SceI sites were infected with the control pQCXIP retrovirus (−) and the pQCXIP-ISceI retrovirus containing the I-SceI gene (+). The pooled puror cultures of infected cells were then plated into medium containing 50 μM ganciclovir to determine the percentage of Ganr cells in the population. The standard deviations are shown for the 3 separate experiments.