Table 2.
KCN inhibition of rate of peroxidation of unbound UCB by HRP (Kp)
| Relative Kpa | ||
|---|---|---|
| vs control | vs LMb or BMc | |
| Control (n = 18) | 100 ± 3.1 | |
| 0.5 mM KCN (n = 12) | 84.7 ± 5.8 (p < 0.001) | |
| 1.0 mM KCN (n = 11) | 73.4 ± 5.8 (p < 0.001) | |
| BMb (n = 11) | 99.2 ± 4.4 (p = 0.618) | |
| 0.5 mM KCN (n = 6) | 88.7 ± 3.3 (p < 0.001) | 89.4 ± 3.4 (p < 0.001) |
| 1.0 mM KCN (n = 6) | 72.1 ± 6.8 (p < 0.001) | 72.1 ± 6.9 (p < 0.001) |
| LMc (n = 12) | 172 ± 6.2 (p < 0.001) | |
| 0.5 mM KCN (n = 6) | 102 ± 8.1 (p = 0.580) | 59.4 ± 4.7 (p < 0.001) |
| 1.0 mM KCN (n = 6) | 83.8 ± 9.3 (p < 0.001) | 48.8 ± 5.4 (p < 0.001) |
a Percent of Kp values normalized to control (no mitochondria); b BM, mouse brain mitochondria; c LM, mouse liver mitochondria.