Table 1.
Expression of NIS in different tissues and its regulation by different thyroid statuses
| NIS | TSHR | TTF1 | Pax8 | TH response | |
|---|---|---|---|---|---|
| Stomach | +++ | + | - | - | No |
| Thyroid | +++ | +++ | + | + | Yes |
| Submandibular gland | ++ | + | - | - | No |
| Colon | + | + | - | - | No |
| Testis | + | ++ | - | - | No |
| Lung | + | + | + | - | Inverse |
| Liver | - | + | - | - | No |
| Pancreas | - | + | - | - | No |
In the columns of NIS and TSHR, relative transcription levels obtained from end-point RTPCR are displayed as '+++', '++', '+' in descending order of expression, and negative expression is displayed as '-'. In the columns of TTF1 and Pax8, presence or absence of transcription are displayed as '+' and '-', respectively. Existence of thyroid-like responsiveness of NIS mRNA expression to thyroid hormone (up-regulated against methimazole and down-regulated against L-T4) is displayed as 'Yes', no-regulatory effect is displayed as 'No', and responsiveness in an inverse direction to thyroid (down-regulated against methimazole and up-regulated against L-T4) is displayed as 'Inverse' in the column of TH response. 'TH' stands for thyroid hormone.