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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Card Fail. 2010 Mar 19;16(7):572–578. doi: 10.1016/j.cardfail.2010.01.006

Table 4.

Interaction effects of NT-pro BNP by depressive symptoms on cardiac event-free survival in patients with heart failure

N = 210

Characteristics Unadjusted
HR
(95% CI)		 P* Adjusted
HR
(95% CI)		 P**
NT-pro BNP ≤ 581 pg/ml 1.00 1.00
NT-pro BNP > 581 pg 2.13
(1.04-4.36)		 .038 1.80
(0.81-3.97)		 .151
Depressive
symptoms (total
PHQ-9 score≥10)		 NT-pro BNP ≤ 581 pg/ml 1.00
NT-pro BNP > 581 pg/ml 3.26
(1.42-7.48)		 .005 3.48
(1.04 - 11.69)		 .043
*

; P value for the interaction effect of NT-pro BNP by depressive symptoms = .001

**

; P value for the interaction effect of NT-pro BNP by depressive symptoms = .029

CI; confidence interval, NT-pro BNP; N-terminal pro B-type natriuretic peptide, PHQ-9; the Patient Health Questionnaire 9

Adjusted hazard ratio (HR) was obtained from controlling for age, gender, etiology of HF, BMI, NYHA class, LVEF, and total comorbidity score.