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. 2010 Jul 9;5(7):e11514. doi: 10.1371/journal.pone.0011514

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Valbuena, Moreno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Under good nutritional conditions, the PKA and TOR pathways inhibit Ste11 nuclear accumulation. (B) When the cells are starved for nitrogen Ste11 accumulates in the nucleus, activates the transcription of its target genes, and promotes sexual differentiation. (C) When the PKA pathway is constitutively active it represses Rst2 activity, and there is no Ste11-dependent gene expression. In this situation, sexual differentiation is repressed even if Tor2 is inactivated.