Figure 1.

Schematic to show the process of finding the potential function of significant SNPs. rs2901126 is a supposed significant SNP but is not located on a gene and has no known biological effect (as is the case for most WGAS derived significant SNPs). Is it a false positive? In this example, rs2901126 is in linkage disequilibrium to an untagged SNP (a SNP not on the genotyping array). The untagged SNP can be linked to gene functions that may provide an indication it contributes to variation in a complex trait. Therefore, rs2901126 is potentially a reliable DNA marker.