Table 4. Curated gene set enrichment analysis results.

Gene Set	Enriched at 24H	24H P-Value	24H FDR	Enriched at 48H	48H P-Value	48H FDR	Enriched at 72H	72H P-Value	72H FDR
SERUM_FIBROBLAST_CELLCYCLE	Forskolin	0.012	0.053	Forskolin	<0.001	<0.001	Forskolin	<0.001	<0.001
HSA04110_CELL_CYCLE	Forskolin	0.002	0.014	Forskolin	<0.001	<0.001	Forskolin	<0.001	<0.001
CELL_CYCLE	Forskolin	<0.001	0.004	Forskolin	<0.001	<0.001	Forskolin	<0.001	<0.001
CELL_CYCLE_KEGG	Forskolin	<0.001	0.004	Forskolin	<0.001	<0.001	Forskolin	<0.001	<0.001
GOLDRATH_CELLCYCLE	Forskolin	0.018	0.061	Forskolin	<0.001	<0.001	Forskolin	<0.001	0.002
CELL_CYCLE_CHECKPOINT	Forskolin	<0.001	0.003	Forskolin	0.002	0.008	Forskolin	<0.001	0.003
G1_TO_S_CELL_CYCLE_REACTOME	Forskolin	<0.001	0.002	Forskolin	0.006	0.023	Forskolin	0.013	0.054
BRENTANI_CELL_CYCLE	Forskolin	<0.001	0.004	Forskolin	<0.001	<0.001	Forskolin	0.018	0.059
HSA04330_NOTCH_SIGNALING_PATHWAY	Forskolin	0.577	0.679	Forskolin	0.037	0.084	Forskolin	0.896	0.949
STEMCELL_COMMON_UP	Forskolin	<0.001	0.001	Forskolin	<0.001	<0.001	Forskolin	<0.001	<0.001
STEMCELL_COMMON_DN	Control	0.107	0.294	Control	<0.001	0.022	Control	<0.001	0.008
REN_E2F1_TARGETS	Forskolin	0.141	0.278	Forskolin	0.002	0.007	Forskolin	<0.001	0.001
VERNELL_PRB_CLSTR1	Forskolin	0.006	0.054	Forskolin	<0.001	<0.001	Forskolin	<0.001	<0.001
BRENTANI_DEATH	Forskolin	<0.001	0.004	Forskolin	0.039	0.094	Forskolin	0.853	0.914
HSA04210_APOPTOSIS	Forskolin	<0.001	0.017	Forskolin	0.004	0.012	Forskolin	0.016	0.049
APOPTOSIS	Forskolin	0.002	0.010	Forskolin	0.004	0.044	Control	0.308	0.454
APOPTOSIS_GENMAPP	Forskolin	0.016	0.052	Forskolin	0.002	0.019	Forskolin	0.146	0.256
PASSERINI_APOPTOSIS	Forskolin	0.085	0.207	Forskolin	0.015	0.034	Control	0.045	0.132

Shown are the curated gene set enrichment analysis results for selected gene sets of interest at 24, 48, and 72 hours. The gene sets shown here were downloaded from the BROAD Institute website and represent empirically defined sets of genes. References for each gene set are provided in the text. Italicized are those gene sets with p-value <0.05 and false discovery rate (FDR) <0.25, which are taken as significant. Gene sets are directly as they appear in the Molecular Signatures Database on the Broad Institute website.