Table 5.

Saccharin, water, and total fluid intake 3 and 23 h after varenicline administration in β2WT and β2KO mice

Varenicline (mg/kg)	Hours of drinking
	3h		23h
	Water (ml)	Total fluid (ml)	Saccharin (mg/kg)	Water (ml)	Total fluid (ml)
β2WT—saline	0.23±0.05	1.55±0.15	104.72±7.03	0.47±0.08	7.29±0.54
β2WT—1	0.23±0.10	1.25±0.10	94.35±10.15	0.61±0.31	6.76±0.51
β2WT—2	0.14±0.05	1.02±0.15a	88.50±8.40	0.43±0.21	6.12±0.48
β2KO—saline	0.18±0.07	1.00±0.08b	83.21±4.74	0.53±0.25	5.91±0.50
β2KO—1	0.07±0.03	1.25±0.14	87.55±5.76	0.23±0.10	5.94±0.43
β2KO—2	0.12±0.09	0.83±0.15c	73.33±12.34	1.07±0.34	5.78±0.64

^aRepresents significantly less than β2 WT—saline (p<0.05)

^bRepresents significantly less than β2 WT—saline (p<0.05)

^cRepresents significantly less than β2 KO—1 mg/kg varenicline (p<0.05)