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. Author manuscript; available in PMC: 2011 Jul 9.
Published in final edited form as: Circ Res. 2010 May 6;107(1):106–116. doi: 10.1161/CIRCRESAHA.109.214601

Figure 4.

Figure 4

Attenuation of angiotensin II-induced hypertension in C57Blk/6 mice by mitoTEMPO. (A) Systolic blood pressure in mice infused for 14 days with saline, angiotensin II (Ang II, 0.7 mg/kg/day) or co-infused with mitoTEMPO (50, 150 and 500 μg/kg/day) or TEMPOL. Systolic blood pressure was measured using tail-cuff plethysmography. (B) Telemetric measurements of systolic blood pressure in mice infused with saline, angiotensin II or co-infused with mitoTEMPO (150 μg/kg/day). Blood pressure values represent mean ± SEM for 5-7 animals per group. *P<0.01 vs control, ** P <0.01 vs Ang II. Following 14 days infusion with saline, angiotensin II or co-infusion with mitoTEMPO (150 μg/kg/day) aortic tissue was isolated for measurements of O2∸ with DHE and HPLC (C) or nitric oxide ESR and Fe(DETC)2 (D). Results represent mean ± SEM for 5-7 animals per group. *P<0.05 vs control, ** P <0.05 vs Ang II.