Table 4.

Multivariate hazard ratios (HR) and 95% confidence intervals (CI) according to category of vitamin C and vitamin E intake and glioma risk

Vitamin intake	Category of intake					p- trend	p-sex interaction
Vitamin C- dietary	Q1	Q2	Q3	Q4	Q5
Median intake*	35	59	80	107	160
Number of cases	98	113	143	116	115
Multivariate HR†	1.00	1.15	1.47	1.22	1.26	0.19	0.89
95% CI	(ref)	0.87–1.50	1.14–1.91	0.93–1.61	0.96–1.66
Vitamin C- supplemental‡	0	>0–99	100–499	500–999	>=1,000
Median intake‡	0	60	203	560	1,060
Number of cases	189	104	106	105	81
Multivariate HR†	1.00	0.93	1.40	1.34	1.09	0.19	0.15
95% CI	(ref)	0.73–1.19	1.10–1.78	1.06–1.70	0.84–1.41
Vitamin E – dietary	Q1	Q2	Q3	Q4	Q5
Median intake§	6.2	7.6	8.6	9.8	12.1
Number of cases	108	109	122	127	119
Multivariate HR†	1.00	1.01	1.15	1.23	1.17	0.12	0.042
95% CI	(ref)	0.77–1.31	0.89–1.49	0.95–1.59	0.90–1.53
Vitamin E – dietary (males)
Number of cases	84	89	86	95	65
Multivariate HR†	1.00	1.13	1.17	1.41	1.04	0.50
95% CI	(ref)	0.84–1.52	0.87–1.58	1.05–1.89	0.75–1.44
Vitamin E – dietary (females)
Number of cases	24	20	36	32	54
Multivariate HR†	1.00	0.66	1.04	0.83	1.28	0.072
95% CI	(ref)	0.36–1.19	0.62–1.74	0.49–1.40	0.79–2.07
Vitamin E- supplemental||	0	>0–99	100–399	400–799	>=800
Median intake||	0	30	221	430	830
Number of cases	195	169	57	133	31
Multivariate HR†	1.00	1.09	1.05	1.27	1.02	0.27	0.42
95% CI	(ref)	0.89–1.34	0.78–1.41	1.02–1.58	0.70–1.49

^*mg/1,000 kcal per day.

^†Adjusted for sex, age (continuous), race (non-Hispanic White, non-Hispanic Black, other, and missing), energy intake (continuous), education (<high school, high school graduate, post-high school other than college, some college, college graduate, postgraduate, and missing), height (8 pre-specified categories and missing), and history of cancer at baseline (yes, no, and missing).

^‡mg per day.

^§IU/1,000 kcal per day.

^||IU per day