Table 6.
Multivariate hazard ratios (HR) and 95% confidence intervals (CI) according to dietary intakes at ages 12–13 and glioma risk
| Intake | Quintile of intake |
||||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | p-trend | p-sex interaction | |
| Processed meat | |||||||
| Median intake* | 5.4 | 13.5 | 21.1 | 30.2 | 45.5 | ||
| Number of cases | 59 | 55 | 49 | 91 | 64 | ||
| Multivariate HR† | 1.00 | 0.91 | 0.80 | 1.41 | 0.97 | 0.45 | 0.54 |
| 95% CI | (ref) | 0.63–1.32 | 0.54–1.17 | 1.00–1.99 | 0.66–1.40 | ||
| Nitrite plus nitrate, processed meat sources | |||||||
| Median intake‡ | 0.37 | 0.99 | 1.70 | 2.51 | 3.94 | ||
| Number of cases | 55 | 59 | 49 | 86 | 69 | ||
| Multivariate HR† | 1.00 | 1.05 | 0.86 | 1.47 | 1.16 | 0.16 | 0.44 |
| 95% CI | (ref) | 0.72–1.52 | 0.58–1.28 | 1.03–2.08 | 0.80–1.67 | ||
| Red meat | |||||||
| Median intake* | 22.1 | 39.0 | 51.5 | 64.7 | 85.7 | ||
| Number of cases | 61 | 54 | 62 | 72 | 69 | ||
| Multivariate HR† | 1.00 | 0.86 | 0.98 | 1.13 | 1.08 | 0.33 | 0.55 |
| 95% CI | (ref) | 0.60–1.25 | 0.68–1.40 | 0.79–1.60 | 0.76–1.54 | ||
| Dietary vitamin C | |||||||
| Median intake‡ | 17 | 25 | 36 | 54 | 84 | ||
| Number of cases | 63 | 66 | 68 | 58 | 63 | ||
| Multivariate HR† | 1.00 | 1.04 | 1.07 | 0.93 | 1.03 | 0.93 | 0.63 |
| 95% CI | (ref) | 0.73–1.47 | 0.76–1.51 | 0.65–1.33 | 0.72–1.47 | ||
| Joint intake§ Nitrite plus nitrate/dietary vitamin C | Low/high | Low/low | High/high | High/low | p-joint interaction |
|---|---|---|---|---|---|
| Nitrite plus nitrate, processed meat sources, median intake‡ | 0.84 | 0.84 | 2.77 | 2.77 | |
| Dietary vitamin C, median intake‡ | 59 | 23 | 59 | 23 | |
| Number of cases | 72 | 67 | 77 | 102 | |
| Multivariate HR† | 1.00 | 1.01 | 1.12 | 1.32 | 0.50 |
| 95% CI | (ref) | 0.73–1.42 | 0.81–1.56 | 0.97–1.81 |
g/1,000 kcal per day (where kcal based on energy intake at ages 12–13).
Adjusted for sex, age (continuous), race (non-Hispanic White, non-Hispanic Black, other, and missing), energy intake at baseline (continuous), education (<high school, high school graduate, post-high school other than college, some college, college graduate, postgraduate, and missing), height (8 pre-specified categories and missing), history of cancer at baseline (yes, no, and missing), energy intake at ages 12–13 (continuous), BMI at age 18 (5 pre-specified categories and missing), and physical activity at ages 15–18 (quintiles of metabolic equivalent-hours per week and missing).
mg/1,000 kcal per day (where kcal based on energy intake at ages 12–13).
Low-high distinctions based on median intake values.