Table 4.
Association of cancer prevention clinical trial barrier subscale items to first-degree relative responses to: “I would participate in a cancer prevention clinical trial if it was offered to me.”
| Agreement with the statement, “I would participate in a cancer prevention clinical trial if it was offered to me.”a | ||||
|---|---|---|---|---|
| Cancer prevention clinical trial barrier subscales and subscale items | Less willing to participateb | More willing to participateb | Total | p |
| 37 (45%) | 45 (55%) | 82 (100%) | ||
| Information Sources | ||||
| I would be interested in a cancer prevention clinical trial that: | ||||
| My relatives cancer doctor told me about. | 11/37 (30%) | 31/44 (70%) | 42/81 (52%) | <0.001 |
| My doctor told me about. | 10/37 (27%) | 31/44 (70%) | 41/81 (51%) | <0.001 |
| A family member told me about. | 4/37 (11%) | 25/44 (57%) | 29/81 (36%) | <0.001 |
| I heard about on the news. | 2/27 (5%) | 13/44 (30%) | 15/81 (19%) | 0.026 |
| I learned about on the internet. | 0/36 (0%) | 8/44 (18%) | 8/80 (10%) | 0.025 |
| Preferences for Prevention Approaches | ||||
| I would be interested in a cancer prevention clinical trial even if: | ||||
| I had to take vitamins or minerals. | 12/37 (32%) | 30/43 (70%) | 42/80 (53%) | <0.001 |
| I had to follow a special diet or exercise program. | 12/37 (32%) | 31/45 (69%) | 43/82 (53%) | <0.001 |
| It involved complementary/alternative medicine approaches. | 9/37 (24%) | 21/44 (48%) | 30/81 (37%) | 0.039 |
| There was a chance of taking a placebo. | 4/37 (11%) | 25/43 (58%) | 29/80 (37%) | <0.001 |
| I might experience side effects from the treatment. | 4/37 (11%) | 16/43 (37%) | 20/80 (25%) | 0.035 |
| I had to take a prescribed medicine by mouth daily. | 2/36 (6%) | 17/44 (39%) | 19/80 (24%) | 0.001 |
| I had to take an injection in my arm for only three months. | 2/37 (5%) | 16/44 (36%) | 18/81 (22%) | 0.003 |
| I had to take an injection in my arm each week. | 1/37 (3%) | 13/43 (30%) | 14/80 (18%) | 0.004 |
| I had to take an injection in my arm monthly for the rest of life. | 2/37 (5%) | 12/44 (27%) | 14/81 (17%) | 0.042 |
| Experimental treatments were riskier than standard approach. | 2/36 (6%) | 12/43 (28%) | 14/79 (18%) | 0.039 |
| Psychosocial Factors | ||||
| I believe that participating in cancer prevention clinical trials: | ||||
| Is important to find ways to prevent cancer. | 20/37 (54%) | 41/45 (91%) | 61/82 (74%) | <0.001 |
| Would benefit others. | 24/37 (65%) | 39/43 (91%) | 63/80 (79%) | 0.009 |
| Would benefit me. | 9/37 (24%) | 37/43 (86%) | 46/80 (58%) | <0.001 |
| Would decrease my risk of cancer. | 3/37 (8%) | 20/44 (45%) | 23/80 (29%) | 0.001 |
| The thought of participating in clinical research makes me hopeful. | 7/37 (19%) | 25/44 (57%) | 32/80 (40%) | 0.003 |
| I feel hopeful when I think about how a cancer prevention clinical trial might benefit me in particular. | 12/37 (32%) | 26/45 (58%) | 38/82 (47%) | 0.006 |
| I would be able to handle the requirements of taking part in a cancer prevention clinical trial. | 6/37 (17%) | 31/44 (70%) | 37/80 (46%) | <0.001 |
| I [do not] believe that participating in a cancer prevention clinical trial would harm me. | 24/37 (65%) | 40/44 (91%) | 64/80 (80%) | 0.006 |
a
Participants were asked to rate their agreement with statement. Five choices were offered in Likert fashion (Not at all, A little, Some, Moderately, and A lot). “Less willing to participate” includes those responding Not at all, A little, or Some, while “More willing to participate” includes those responding Moderately and A lot.
b
Column percents for subscale items. Some denominators may be reduced due to non-response by participants.