Table 3.
Tumor endothelial cell expression of KIT, phosphorylated KIT, SCF and VEGFR‐2 in 84 pediatric brain tumors. Abbreviations: N = number of cases; SCF = stem cell factor; VEGFR‐2 = vascular endothelial cell growth factor receptor‐2; PNET = primitive neuroectodermal tumor; DNT = dysembryoblastic neuroepithelial tumor; SEGA = subependymal giant cell astrocytoma; PXA = pleomorphic xanthoastrocytoma.
| Histological diagnosis | N | Age or median age (range) | KIT | phospho‐KIT | SCF | VEGFR‐2 |
|---|---|---|---|---|---|---|
| −/+/++/+++ | −/+/++/+++ | −/+/++/+++ | −/+/++/+++ | |||
| Pilocytic astrocytoma | 35 | 10 (0–18) | 12/10/6/7 | 16/8/4/6* | 24/7/0/0* | 26/5/0/0* |
| Ependymoma | 11 | 4 (0–17) | 2/3/5/1 | 1/5/2/3 | 9/2/0/0 | 9/1/1/0* |
| Medulloblastoma | 12 | 9 (1–20) | 7/4/1/0 | 4/5/2/0* | 10/0/0/0* | 3/4/0/0* |
| DNT | 7 | 12 (6–17) | 5/2/0/0 | 0/5/2/0 | 7/0/0/0 | 7/0/0/0* |
| Ganglioglioma | 4 | 11.5 (8–19) | 4/0/0/0 | 3/1/0/0 | 4/0/0/0 | 3/0/0/0* |
| Craniopharyngioma | 3 | 17 (10–19) | 1/0/0/0* | 3/0/0/0 | 1/0/0/0* | 0/0/0/0* |
| Astrocytoma | 1 | 17 (17) | 1/0/0/0 | 0/1/0/0 | 1/0/0/0 | 0/1/0/0 |
| SEGA | 2 | 12 (8–16) | 2/0/0/0 | 1/1/0/0 | 2/0/0/0 | 2/0/0/0 |
| Anaplastic astrocytoma | 2 | 9 (7–11) | 1/1/0/0 | 1/0/1/0 | 2/0/0/0 | 1/1/0/0 |
| Chroid plexus papilloma | 2 | 1.5 (0–3) | 1/1/0/0 | 2/0/0/0 | 2/0/0/0 | 1/1/0/0 |
| Oligodendroglioma | 2 | 13 (7–19) | 1/0/0/0* | 1/1/0/0 | 2/0/0/0 | 2/0/0/0 |
| Oligoastrocytoma | 1 | 19 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 |
| PXA | 1 | 15 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 |
| PNET | 1 | 2 | 1/0/0/0 | 0/1/0/0 | 1/0/0/0 | 1/0/0/0 |
| Total | 84 | 10 (0–20) | 40/21/12/8 | 34/28/11/9 | 67/9/0/0 | 56/13/1/0 |
*
Immunostaining was not informative, or a representative sample tissue was not available in one or more cases.