Table 4.
Tumor cell expression of KIT, phosphorylated KIT, SCF and VEGFR‐2 in 84 pediatric brain tumors. Abbreviations: N = number of cases; SCF = stem cell factor; VEGFR‐2 = vascular endothelial cell growth factor receptor‐2; PNET = primitive neuroectodermal tumor; DNT = dysembryoblastic neuroepithelial tumor; SEGA = subependymal giant cell astrocytoma; PXA = pleomorphic xanthoastrocytoma.
| Histological diagnosis | N | KIT | phospho‐KIT | SCF | VEGFR‐2 |
|---|---|---|---|---|---|
| −/+/++/+++ | −/+/++/+++ | −/+/++/+++ | −/+/++/+++ | ||
| Pilocytic astrocytoma | 35 | 29/6/0/0 | 30/4/0/0* | 24/6/1/0* | 10/15/6/0* |
| Ependymoma | 11 | 9/2/0/0 | 7/3/1/0 | 8/3/0/0 | 5/4/2/0 |
| Medulloblastoma | 12 | 7/5/0/0 | 8/3/0/0* | 9/1/0/0* | 6/1/0/0* |
| DNT | 7 | 6/0/1/0 | 6/1/0/0 | 7/0/0/0 | 7/0/0/0 |
| Ganglioglioma | 4 | 2/2/0/0 | 4/0/0/0 | 2/2/0/0 | 3/0/0/0* |
| Craniopharyngioma | 3 | 0/3/0/0 | 3/0/0/0 | 1/0/0/0* | 3/0/0/0 |
| Astrocytoma | 1 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 |
| SEGA | 2 | 1/1/0/0 | 1/1/0/0 | 1/1/0/0 | 1/1/0/0 |
| Anaplastic astrocytoma | 2 | 2/0/0/0 | 2/0/0/0 | 2/0/0/0 | 0/2/0/0 |
| Chroid plexus papilloma | 2 | 0/2/0/0 | 2/0/0/0 | 2/0/0/0 | 2/0/0/0 |
| Oligodendroglioma | 2 | 0/1/0/0* | 2/0/0/0 | 1/1/0/0 | 1/0/1/0 |
| Oligoastrocytoma | 1 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 |
| PXA | 1 | 1/0/0/0 | 1/0/0/0 | 1/0/0/0 | 0/0/0/0* |
| PNET | 1 | 0/1/0/0 | 0/1/0/0 | 0/1/0/0 | 0/1/0/0 |
| Total | 84 | 59/23/1/0 | 68/13/1/0 | 60/15/1/0 | 40/24/9/0 |
*
Immunostaining was not informative, or a representative tissue sample was not available in one or more cases.