Table 1.

TERT SNP genotype and mean telomere length.

	δΔCt (95%CI)
TERT rs401681	Breast Cancer 6434 controls	Melanoma 979 controls	SIBS 1655 controls	Colorectal Cancer 2246 controls	Combined 11314 controls
CC	0.00 ref	0.00 ref	0.00 ref	0.00 ref	0.00 ref
CT	−0.002 (−0.02 - 0.02)	0.06 (0.003 - 0.1)	−0.002 (−0.04 - 0.04)	0.01 (−0.02 - 0.05)	0.02 (−0.005 - 0.04)
TT	−0.02 (−0.03 - 0.02)	0.03 (−0.05 - 0.1)	0.03 (−0.02 - 0.08)	0.004 (−0.04 - 0.05)	0.04 (−0.03 - 0.04)
Per T allele	p-trend=0.86	p-trend=0.38	p-trend=0.29	p-trend=0.78	p-trend=0.61

Genotype frequencies and mean telomere length, as represented by the continuous ΔCt variable, were analysed in control samples using linear regression, for the ‘per T allele’ change in mean telomere length (δΔCt), with associated 95% confidence intervals (95% CI). Analyses were adjusted for 384-well plate and age in all the studies and for gender and family where applicable.