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. Author manuscript; available in PMC: 2011 Jul 9.
Published in final edited form as: Circ Res. 2010 May 6;107(1):126–137. doi: 10.1161/CIRCRESAHA.110.219949

Figure 2.

Figure 2

Effects of the SCN5A mutations on Na+ current in SAN cells. A: percentage increase of the fast and slow Na+ channel inactivation time constants from the WT channel to T220I, P1298L, delF1617 and E161K mutant channels. B: simulated steady-state activation curve for Na+ channel. C: simulated steady-state inactivation curves for Na+ channel. D: relative (to the WT channel) shift of the steady-state inactivation curve from experimental data. E: normalised simulated Na+ channel current density. E: percentage reduction in Na+ current density from the WT channel. For mutation parameter values see Online Table I.