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Effects of ACh and the SCN5A mutations on AP conduction. AP profiles in the 2D tissue with [ACh] = 0 (left) and [ACh] = 1.5 ×10−8 mol/L (right) are shown. A, B: tissue with the WT channel. C, D: tissue with the P1298L mutant channel. E, F: tissue with the E161K mutant channel.
