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Effects of ACh and the SCN5A mutations on AP conduction parameters: activation times with the E161K mutation and ACh (A) and the P1298L mutation (B) as compared to the WT channel; conduction velocities with the E161K mutation and ACh (C) and the P1298L mutation (D) as compared to the WT channel; dV/dtmax with the E161K mutation and ACh (E) and the P1298L mutation (F) as compared to the WT channel. [ACh] = 1.5 ×10−8 mol/L.
