Table 1.
Baseline characteristics of hypertensive patients with type 2 diabetes and normoalbuminuria according to availability of fundus evaluation YES/NO, evidence of retinopathy at study entry YES/NO, and to randomization to ACE inhibitor therapy YES/NO and ndCCB therapy YES/NO.
| Funduscopy Yes | Funduscopy No | Retinopathy Yes | Retinopathy No | With Retinopathy | ||||
|---|---|---|---|---|---|---|---|---|
| ACEi Yes | ACEi No | ndCCB Yes | ndCCB No | |||||
|
| ||||||||
| Number of patients | 550 | 659 | 90 | 460 | 42 | 48 | 50 | 40 |
| Demography | ||||||||
| Age (yrs) | 62.0 ± 7.8 | 62.6 ± 8.2 | 61.3 ± 7.9 | 62.1 ± 7.8 | 61.5 ± 7.7 | 61.1 ± 8.1 | 60.8 ± 8.4 | 62.0 ± 7.1 |
| Males (n) | 294 (53.5) | 345 (52.3) | 48 (53.3) | 246 (53.5) | 24 (57.1) | 24 (50.0) | 30 (60.0) | 18 (45.0) |
| Clinics | ||||||||
| BMI (kg/m2) | 28.7 ± 4.5 | 29.4 ± 4.9* | 28.3 ± 4.0 | 28.8 ± 4.6 | 28.0 ± 3.3 | 28.6 ± 4.5 | 28.4 ± 4.0 | 28.1 ± 4.0 |
| Diabetes duration (yrs) | 7.9 ± 6.6 | 7.4 ± 6.5 | 10.5 ± 7.2 | 7.4 ± 6.3°°° | 11.2 ± 7.5 | 9.9 ± 7.1 | 10.9 ± 7.0 | 10.1 ± 7.6 |
| Smokers | ||||||||
| Never | 323 (58.7) | 377 (57.2) | 58 (64.4) | 265 (57.6) | 24 (57.1) | 34 (70.8) | 31 (62.0) | 27 (67.5) |
| Former | 169 (30.7) | 194 (29.4) | 24 (26.7) | 145 (31.5) | 14 (33.3) | 10 (20.8) | 15 (30.0) | 9 (22.5) |
| Current | 58 (10.5) | 88 (13.3) | 8 (8.9) | 50 (10.9) | 4 (9.5) | 4 (8.3) | 4 (8.0) | 4 (10.0) |
|
| ||||||||
| Laboratory | ||||||||
| HbA1c (%) | 5.9 ± 1.5 | 5.7 ± 1.3** | 6.5 ± 1.5 | 5.8 ± 1.4°°° | 6.6 ± 1.4 | 6.5 ± 1.7 | 6.6 ± 1.7 | 6.4 ± 1.2 |
| Systolic BP (mm Hg) | 151.6 ± 14.3 | 149.3 ± 12.9* | 158.4±16.5 | 150.3 ± 13.5°°° | 161.2 ± 15.3 | 155.9±17.2 | 154.3±15.2 | 189.0 ± 55.6 |
| Diastolic BP (mm Hg) | 88.8 ± 8.3 | 86.4 ± 6.9*** | 90.7 ± 8.2 | 88.4 ± 8.3° | 92.4 ± 7.9 | 89.1±8.3 | 89.9±8.5 | 91.6 ± 7.9 |
| Albuminuria (μg/min) | 6.8 ± 4.5 | 7.0 ± 4.6 | 8.1 ± 5.1 | 6.6 ± 4.4°° | 8.0 ± 5.0 | 8.2 ± 5.2 | 8.3 ± 5.4 | 7.8 ± 4.6 |
| Ser. creatinine (mg/dL) | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.2 |
| Triglycerides (mg/dL) | 143.5 ± 73.2 | 151.7 ± 83.4 | 146.3 ± 75.0 | 142.9 ± 72.9 | 146.7 ± 64.9 | 145.9 ± 83.6 | 139.7 ± 80.1 | 154.4 ± 68.2 |
| Tot. Cholesterol (mg/dL) | 212.0 ± 36.5 | 208.5 ± 35.1 | 213.1 ± 40.5 | 211.8 ± 35.7 | 207.7 ± 31.2 | 217.8 ± 46.9 | 209.4 ± 37.3 | 217.7 ± 44.1 |
Data are mean ± SD or numbers and percentages (in brackets).
*P < .05, **P < .01, ***P ≤ .001 versus Fundoscopy YES; °P < .05, °°P < .01, °°°P ≤ .001 versus Retinopathy YES; ^ P < .01 versus ndCCB YES.