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. Author manuscript; available in PMC: 2010 Jul 11.
Published in final edited form as: Physiol Rev. 2007 Apr;87(2):593–658. doi: 10.1152/physrev.00035.2006

FIG. 12.

FIG. 12

InsP3R channel activities activated by adenophostin A (AdA). [Ca2+]i dependence of mean Po of endogenous X-InsP3R-1 channels in the presence of various ligand (AdA or InsP3) concentrations as tabulated in 0.5 mM [ATP]free (A) or 0 [ATP]free (B). The curves are biphasic Hill equation (Eq. 2) fit to the data using parameters as tabulated. Typical single-channel current traces of X-InsP3R-1 in outer nuclear membrane recorded at optimal [Ca2+]i and saturating 100 nM AdA in 0.5 mM [ATP]free with channel Po of 0.72 (C) and 0 [ATP]free with channel Po of 0.39 (D). [Modified from Mak et al. (279).]