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The InsP3R Ca2+ release channel. Cartoon depicting three of four InsP3R molecules (in different colors) in a single tetrameric channel structure. Part of the luminal loop connecting transmembrane helices 5 and 6 of each monomer dips into the fourfold symmetrical axis, creating the permeation pathway for Ca2+ efflux from the lumen of the endoplasmic reticulum.
