TABLE 3.

Clinical application of macrolides

Disease	Recommendation for routine use	Expected efficacy	Outstanding issues or comments
Asthma	Discouraged (few patients)	Steroid-sparing effect	Insufficient evidence, small study population
Bronchiectasis	Partially recommended	Decreased sputum, reduced exacerbations	Few data, small number of patients, short duration
COPD	Discouraged	Reduced exacerbations	Insufficient evidence, small study population
Chronic rhinosinusitis	Partially recommended (for noneosinophilic cases)	Reduced nasal mucus, improved quality of life	Study design, study population
Cystic fibrosis	Recommended	Reduced exacerbations, less deterioration in pulmonary functions	Short duration
DPB	Recommended	Improved prognosis, potential cure	First-line therapy
Influenza/sepsis	Discouraged	Improved prognosis	Insufficient evidence
Posttransplantation BOS	Discouraged	Improved prognosis	Insufficient evidence