FIG. 14.

Schematic diagram of three pathways in the PTS network that regulate biofilm formation. Pathway 1 requires phosphorylation of the PTS components EI and HPr or FPr to repress transcription of the vps genes. Pathway 2a is comprised of the components EIIBC^Glc, Mlc, and EIIA^Glc. EIIA^Glc activates vps transcription in a phosphorylation-independent manner. Mlc potentiates the action of EIIA^Glc but may also activate vps gene transcription through an EIIA^Glc-independent route (pathway 2b). EIIBC^Glc interferes with the action of Mlc. Pathway 3 includes EIIA^Ntr1and EIIA^Ntr2, whose functions display some redundancy in repression of vps transcription.