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. 2010 Jun 17;47(1):74–80. doi: 10.3164/jcbn.10-02

Fig. 2.

Fig. 2

The effect of tolfenamic acid on cell growth in KB cells. A, Photomicrographs of KB cells treated with 50, 75 and 100 µM of tolfenamic acid for 48 h. The KB cells were treated with DMSO (vehicle control) or various concentrations of tolfenamic acid for 48 h and then observed by optical microscopy. B, The KB cells were treated with DMSO or various concentrations of 50, 75 and 100 µM of tolfenamic acid for 48 h. Cell proliferation was determined using a trypan blue exclusion assay. The points are the mean ± SD of three independent experiments. *p<0.05 compared to the control group. C, The cell viability of KB cells was estimated using a MTT assay. The points are the mean ± SD of three independent experiments. *p<0.05 compared to the control group. D, The apoptotic effect of tolfenamic acid in KB cells. Immunoblot detection of the cleaved poly ADP-ribose polymerase (PARP) in whole cell lysates. Actin was used to normalize the protein loading from each treatment.