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. Author manuscript; available in PMC: 2010 Nov 28.
Published in final edited form as: Mol Cell. 2010 May 28;38(4):551–562. doi: 10.1016/j.molcel.2010.03.014

Figure 4. High throughput sequencing identifies numerous novel precursor snRNAs bound to Gemin5.

Figure 4

Diagrammatic representation of the pre-snRNAs. The mature form of each snRNA is depicted as a gray line and the precursor sequences identified by high throughput sequencing are shown as a dashed red line. Nucleotide numbers for the mature and pre-snRNAs are indicated on the x-axis. Green boxes represent Sm sites. The non-canonical Sm site of U1 is shaded in light green. The previously determined snRNP code is shown as yellow bars beneath each snRNA, except for U4atac, which was identified in this study (hatched yellow bar). Regions of RNA bound to Gemin5, corresponding to high frequency sequence reads from the high throughput sequencing and protected from RNase T1 digestion, are overlayed on the snRNAs as a shaded blue region (see also Table S2).