Table 2.
Baseline Demographic and Clinical Measures by Disease Classification
| Primary Renal Disease | Secondary Renal Disease | |||
|---|---|---|---|---|
| WT (n=29) |
Variant (n = 7) |
WT (n=18) |
Variant (n=5) |
|
| Age (yrs) | 43.5 (17.8) | 49.9 (15.7) | 64.2 (14.1) | 67.4 (8.05) |
| Weight (kg) | 83.1 (20.6) | 96.8 (13.7)+ | 89.7 (24.6) | 71.7 (23.4) |
| Gender (%female) | 65% | 86% | 50% | 80% |
| Losartan dose (mg/day) | 56 (29) | 67 (38) | 63 (29) | 50 (0) |
| SBP (mm Hg) | 131 (20.5) | 136 (12.8) | 141 (17.4) | 128 (13.2) |
| DBP (mm Hg) | 75.3 (9.77) | 82.5 (6.57) | 73.5 (13.0) | 67.4 (14.8) |
| SCr (mg/dL) | 1.63 (0.81) | 1.57 (0.69) | 2.03 (0.71) | 2.04 (1.20) |
| eGFR (mL/min/1.73m2) | 41.6 (22.8) | 36.2 (15.9) | 30.2 (14.4) | 29.8 (19.4) |
| UP (mg/day) | 2632 (4710) | 1365 (3061)* | 2051 (2694) | 340 (232) |
Data presented as mean (standard deviation)
+
p value 0.05,
*
p value 0.07
DBP – diastolic blood pressure; eGFR – estimated glomerular filtration rate via Modification of Diet in Renal Disease equation [14], SBP – systolic blood pressure; SCr – serum creatinine, UP – urinary protein to creatinine ratio, WT = wildtype Variant = presence of a *2 and/or *3 allele