Table 3.
Changes in Clinical Parameters by Renal Disease from Baseline to Follow-up
| Primary Renal Disease | |||
|---|---|---|---|
| WT (n = 29) |
Variant (n = 7) |
P value | |
| Δ SBP (mm Hg) | −3.6 (26.3) | −1.7 (14.2) | 0.863 |
| Δ DBP (mm Hg) | −0.2 (13.8) | −1.2 (13.8) | 0.879 |
| Δ SCr (mg/dL) | 0.2 (0.6) | 0.2 (0.8) | 0.606 |
| Δ eGFR (mL/min/1.73m2) | 6.5 (13.6) | 8.5 (14.5) | 0.734 |
| Δ UP (mg/day) | −1278 (4277) | −458 (1651) | 0.139 |
| Δ % UP | −125 (323) | −31.7 (156) | 0.123 |
| Δ Dose (mg) | 9.8 (22.9) | 0 (47.4) | 0.540 |
| Secondary Renal Disease | |||
| WT (n = 18) |
Variant (n = 5) |
P value | |
| Δ SBP (mm Hg) | −5.5 (17.5) | 16.2 (27.1) | 0.044 |
| Δ DBP (mm Hg) | −3.2 (10.6) | 9.8 (16.0) | 0.043 |
| Δ SCr (mg/dL) | −0.02 (0.5) | −0.3 (0.9) | 0.530 |
| Δ eGFR (mL/min/1.73m2) | 2.7 (8.7) | 5.2 (11.6) | 0.493 |
| Δ UP (mg/day) | −1161 (2192) | −5.7 (210) | 0.611 |
| Δ %UP | −67.3 (121) | 1.4 (106) | 0.521 |
| Δ Dose (mg) | 15.3 (24.5) | 20.0 (27.4) | 0.793 |
Data are presented as mean (standard deviation)
DBP – diastolic blood pressure; eGFR – estimated glomerular filtration rate via Modification of Diet in Renal Disease equation [14], SBP – systolic blood pressure; SCr – serum creatinine, UP – urinary protein to creatinine ratio, WT = wild type Variant = presence of a *2 and/or *3 allele