Figure 3.
Effects of increasing doses of isoproterenol (ISO) on isometric force in LV papillary muscle isolated from short- and long-term WT-AoB and iNOSKO-AoB mice and age-matched control mice. Representative trace of the isometric force of papillary muscle isolated from WT-AoB (A) and iNOSKO-AoB (B) mice after short-term banding. Developed force (C) and time to 50% relaxation (D) in short-term AoB mice and age-matched controls. Representative trace of the isometric force of papillary muscle isolated from WT-AoB (E) and iNOSKO-AoB (F) mice after long-term banding. Developed force (G) and time to 50% relaxation (H) in long-term AoB mice and age-matched controls. *Indicates P<0.05 compared to WT; +indicates P<0.05 compared to iNOSKO; #indicates P<0.05 compared to all other groups.