Figure 4.
Hemodynamic parameters in long-term iNOSKO-AoB, WT-AoB mice and age-matched controls. A) Representative pressure-volume loops from iNOSKO-AoB and WT-AoB hearts. The dotted lines represent the end-systolic pressure-volume relationship (ESPVR). B) Left-ventricular systolic pressure (LVSP); C) Preload-load recruitable stroke work (PRSW); D) rates of contraction (dP/dtmax) and relaxation (dP/dtmin). +Significantly different (P<0.05) from iNOSKO; #Significantly different (P<0.05) from all other groups; ‡Significantly different (P<0.05) from WT-AoB.