Table 1.
Echocardiographic measurements in WT-AoB, iNOSKO-AoB and age-matched WT and iNOSKO mice
| Group | HR (bpm) | LVIDd (mm) | LVISd (mm) | FS (%) | Vcf (circ/sec) | IVSDd (mm) | LVPWDd (mm) | E/A | IVRT(msec) |
|---|---|---|---|---|---|---|---|---|---|
| Short-term banding | |||||||||
| WT (n=5) | 464.6±18.2 | 3.80 ±0.15 | 2.21±0.09 | 41.80±1.07 | 8.68±0.85 | 0.69±0.04 | 0.65±0.02 | 1.14±0.06 | 17±2 |
| WT-AoB (n=11) | 379.8±35.7 | 3.81±0.11 | 2.64±0.15+ | 31.34±2.42*+ | 5.96±0.52*+ | 1.01±0.04*+ | 1.02±0.04*+ | 1.28±0.20 | 22±2 |
| INOSKO (n=7) | 462.3±31.3 | 3.63±0.08 | 2.00±0.09 | 45.00±1.63 | 9.73±0.61 | 0.64±0.02 | 0.65±0.02 | 1.31±0.19 | 18±1 |
| INOSKO-AoB (n=9) | 467.3±38.4 | 3.72±0.09 | 2.39±0.14 | 36.42 ±2.48+ | 7.44±0.61+ | 1.05±0.04*+ | 1.05±0.03*+ | 1.21±0.14 | 19±2 |
| Long-term banding | |||||||||
| WT (n=13) | 399.8±17.8 | 3.89±0.09 | 2.47±0.07 | 36.58±1.20 | 7.55±0.33 | 0.75±0.03 | 0.70±0.02 | 1.34±0.08 | 19±1 |
| WT-AoB (n=10) | 441.5±19.1 | 4.11±0.10 | 3.05±0.13# | 26.00±1.43*+ | 5.09±0.36*+ | 1.02±0.03*+ | 1.01±0.04*+ | 1.56±0.33 | 21±2 |
| INOSKO (n=10) | 451.6±26.3 | 3.79±0.08 | 2.41±0.08 | 37.13±1.53 | 7.67±0.44 | 0.67±0.02* | 0.66±0.01 | 1.33±0.10 | 18±1 |
| INOSKO-AoB (n=8) | 368.0±18.4 | 3.90±0.13 | 2.73±0.12 | 30.00±1.15*+ | 5.76±0.29*+ | 1.00±0.03*+ | 0.98±0.02*+ | 1.45±0.17 | 21±1 |
HR=heart rate; LVIDd=Left ventricular internal dimension in diastole; LVISd=LV internal dimension in systole; FS=LV fractional shortening; Vcf =LV circumferential fiber shortening; IVSDd=Interventricular septum dimension in diastole; LVPWDd=LV posterior wall dimension in diastole; E/A=Ratio of the maximal velocity of mitral inflow E (early LV filling) and A (atrial contraction) waves; IVRT=LV isovolumic relaxation time.
*
P<0.05 compared to WT;
+
P<0.05 compared to iNOSKO;
#
P<0.05 compared to all other groups