Table 2.
Hemodynamic parameters in long-term WT-AoB, iNOSKO-AoB and age-matched WT and iNOSKO mice
| Group | HR (bpm) | LVSP (mmHg) | LVDP (mmHg) | dP/dtmax (mmHg/s) | dP/dtmin (mmHg/s) | ESPVR (mmHg/ml) | PRSW (mmHg) | Emax (mmHg/ml) |
|---|---|---|---|---|---|---|---|---|
| WT (n=5) | 571.4± 21.3 | 87.6±5.7 | 3.6±0.4 | 8246.4±822.1 | -8114.2±880.4 | 9.4±3.0 | 70.0±11.8 | 14.2±11.8 |
| WT-AoB (n=7) | 545.6± 24.1 | 94.7±7.3 | 3.3±0.2 | 6346.9±654.2 | -6817.4±830.8 | 12.4±3.8 | 69.4±13.1 | 22.9±11.1 |
| INOSKO (n=8) | 619.8± 13.4 | 91.0±3.6 | 3.0±0.2 | 10244.1±876.5‡ | -8794.4±670.5 | 7.2±1.5 | 56.1±6.8 | 16.2±4.7 |
| INOSKO-AoB (n=8) | 592.5± 17.6 | 131.6±11.0# | 3.3±0.2 | 9791.5±944.8‡ | -11056.6±1196.6‡ | 15.3±2.6 | 114.4±18.0+ | 29.9±4.7 |
HR=heart rate; LVSP=Left ventricular systolic pressure; LVDP=LV diastolic pressure; ESPVR=End-systolic pressure-volume relationship; PRSW=Pre-load recruitable stroke work; Emax=ESPVR slope.
+
P<0.05 compared to iNOSKO;
#
P<0.05 compared to all other groups;
‡
P<0.05 compared to WT-AoB.