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. Author manuscript; available in PMC: 2010 Jul 12.
Published in final edited form as: J Phys Chem B. 2009 Nov 26;113(47):15679–15691. doi: 10.1021/jp9072203

Figure 1.

Figure 1

hIAPP fiber model dervied from the ssNMR data. (a) The sequence of hIAPP with seven isotope labeled residues highlighted: Ala-5 (blue), Ala-8 (red), Ala-13 (orange), Val-17 (yellow), Ala-25 (silver), Leu-27 (green), and Val-32 (pink). (b) Cross section of a fiber demonstrating that the fibers are composed of two columns of random coil/β-sheet/turn/β-sheet structure. (c) Protofiber as viewed from the side with single labeled residue (Ala-13) exhibiting the formation of two isotopically labeled columns.