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Proposed mechanisms of disease for hypoPP and possible potential future therapeutic developments
| Pathomechanism | Target pathway | Potential therapy |
|---|---|---|
| Disrupted intracellular pH homeostasis | Possible role of intracellular carbonic anhydrases | Isoform-specific and membrane-permeable carbonic anhydrase inhibitors |
| Gating pore leak | Aberrant cation permeability | Gating pore ‘blockers’ |
| Inhibition of IRK channels | Reduced sarcolemmal potassium conductance | Potassium channel activators |
