Table 3.

Whole cell parameters for HEK cells expressing P/Q channels with coding variants

	WT	G540R	L621R	E921D:E993V	E1018K	G1105S
τact (ms)	0.53 ± 0.07	0.79 ± 0.12	0.60 ± 0.06	0.80 ± 0.13	0.74 ± 0.22	0.50 ± 0.07
Inactivation	0.83 ± 0.05	0.74 ± 0.03	0.74 ± 0.02	0.72 ± 0.03	0.79 ± 0.05	0.77 ± 0.05

Inactivation is expressed as percentage of peak current remaining at 175 ms after the step. All values are means ±s.e.m. No values are significantly different. Inactivation was measured at a test pulse of +10 mV; n≥ 5 for WT and all mutants.