Figure 2.
KINOMEscan™ profiling of 12. Compounds were screened at a concentration10 μM against 442 kinases and the most potently bound kinases are indicated by red circles and include: ABL, ARG, BLK, PITSLRE, CRIK, FMS/CSFR, DDR1, EphA8, FGFR4, HPK1, JNK2, KIT, LOK, LYN, GCK, MUSK, MYO3B, p38α, p38β, PDGFRα, PDGFRβ, RET, RIPK1, SRC, TAO1, TAO2, TAO3 and TIE2.