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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 May 19;20(14):4196–4200. doi: 10.1016/j.bmcl.2010.05.043

Scheme 2.

Scheme 2

Synthetic route of 12.a

a Reagents and conditions: (a) ethynyltrimethylsilane, Pd(PPh3)4, CuI, DIEA, DMF, 50 °C, 55%; (b) TBAF, THF, RT, 77%; (c) 1, Pd(PPh3)4, CuI, DIEA, DMF, RT, 82%.