Figure 6.

Schematic representation of the brain, spinal cord, and key peripheral and autonomic structures which can be affected by Lewy body disease pathology, and the clinical features associated with dysfunction of each structure. The structures (abbreviations) and likely associated clinical features are as follows: olfactory bulb (OB)=anosmia, tuberomamillary nucleus (TMN)=altered arousal/sleep, lateral hypothalamus (LHT)=hypersomnia, nucleus basalis of Meynert (NBM)=cognitive impairment, hippocampal formation (HF)=cognitive impairment, neocortex (N)=cognitive impairment, substantia nigra (SN)=parkinsonism, pedunculopontine nucleus (PPN)=altered arousal/attention, raphe nucleus (RN)=depression, locus ceruleus (LC)=depression, sublaterodorsal nucleus (SLD)=? RBD, magnocellular reticular formation (MCRF)=? RBD, intermediolateral cell column (ILDN)=orthostatism, sympathetic innervation of the heart (H)=cardiac dysfunction, enteric innervation of the intenstines (I)=constipation, and autonomic innervation of the sex organs (SO)=impotence