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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Ann N Y Acad Sci. 2010 Jan;1184:15–54. doi: 10.1111/j.1749-6632.2009.05115.x

Figure 7.

Figure 7

Schematic representation of the hypothesized progression in motor functioning with increasing age and disease severity in evolving Lewy body disease in the Parkinson's disease-predominant phenotype. The onset of RBD typically begins years or decades prior to the onset of subtle motor signs (mild parkinsonian signs or MPS); such motor signs may be asymptomatic and only detectable on clinical examination. Typical features of Parkinson's disease (PD) evolves months or years later. Over time, PD with mild cognitive impairment (PD+MCI) evolves, followed some time thereafter by parkinsonism which is less levodopa-responsive, and a full dementia syndrome (PD with dementia or PDD) becomes manifest.