Table 1.
Proportions of older patients enrolled in pivotal statin trials.
| Study | Characteristics | Age at enrolment | |
|---|---|---|---|
| ≥65 years | ≥70 years | ||
| Scandinavian Simvastatin Survival Study (4S) [10] | Simavastatin versus placebo Patients aged 35–70 years n = 4444 |
23% | — |
|
| |||
| Cholesterol and Recurring Events (CARE) Trial. Lewis et al. [13] | Pravastatin versus placebo Patients aged 21–75 years n = 4059 |
31% | 12% |
|
| |||
| Heart Protection Study (HPS) [17] | Simavastatin versus placebo Patients aged 40–80 years n = 20 536 |
52% | 28% |
|
| |||
| Treating to New Targets (TNT). Wenger et al. [22] | Atorvastatin 80 mg versus 10 mg Patients aged 35–75 years n = 10 001 |
38% | 18% |