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. 2010 Mar 23;95(6):2857–2867. doi: 10.1210/jc.2009-2320

Figure 2.

Figure 2

A, Schematic of mutations in NK3-R. B, Effects of mutations in TACR3 on NKB-mediated activation of signal transduction. COS-7 cells transfected with wild-type (WT), G18D, I249V, Y256H, R295S, and Y315C NK3-R or EV were treated with NKB (10−7 m) for 1 h. A significant increase in IP accumulation occurred in cells transfected with WT, G18D, or I249V NK3-R. In contrast, there was a marked reduction in NKB-stimulated IP production in cells transfected with Y256H, R295S, or Y315C NK3-R, or with EV. a, b, and c denote significantly different fold increases in IP accumulation.