Table 2.

Cross-sectional associations between baseline circulating sex hormone levels and self-reported mobility limitation at examination 7 (n = 1445)

	Multivariable logistic regression
	Mobility limitation		Subjective health
	OR (95% CI)	P	OR (95% CI)	P
Continuous hormone levels
TT	0.89 (0.70–1.13)	0.34	0.80 (0.63–1.01)	0.06
FT	0.80 (0.61–1.03)	0.09	0.72 (0.56–0.94)	0.01
SHBG	1.13 (0.91–1.40)	0.28	1.05 (0.85–1.31)	0.64
Dichotomized sex hormone levels
Low TT	1.12 (0.62–2.02)	0.70	1.09 (0.62–1.89)	0.77
Low FT	1.29 (0.80–2.08)	0.30	1.61 (1.02–2.55)	0.04
High SHBG	1.31 (0.75–2.28)	0.34	1.20 (0.69–2.09)	0.51

Continuous hormone levels and OR values are for 1 sd change in sex hormone levels. All models were adjusted for age, BMI, smoking, and comorbidities (cancer and cardiovascular disease) at examination 7. Sex hormones were defined as low or high vs. normal using healthy reference sample of FHS Generation 3 men. Low TT and FT levels were those below the 2.5th percentile of the referent sample (TT <348.3 ng/dl; FT <70.0 pg/ml), and SHBG levels above the 97.5th percentile of the referent sample (SHBG, 81.6 nmol/liter) represented high SHBG levels. Low FT levels (<70 pg/ml) were associated with increased risk (OR = 1.61) of poor subjective health; each sd increase in FT level was associated with a 28% decease (OR = 0.72) in risk of reporting poor subjective health.